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OJVRTM
Online Journal of Veterinary Research©
Volume 1: 29-34, 2002.
Acute oral toxicity of glyphosate
in Wistar rats.
Dallegrave Ea, Mantese FDa,
Dalsenter PR,b Langeloh Aa
a Department of Pharmacology, Instituto
de Ciências Básicas da Sáude, Universidade
Federal do
ABSTRACT
Dallegrave E, Mantese
FD, Dalsenter PR, Langeloh
A., Oral acute toxicity of glyphosate in Wistar rats, Online J Vet Res 1:29-36, 2002. The acute toxicity of glyphosate (N-phosphonomethylglycine
with the surfactant polyoxyethyleneamine:Roundup®),
was determined 2, 4, 6, 8, 10, 12 and 24 hours after the oral administration of
1, 2, 3 or 4g/kg to Wistar rats. Each animal was
observed for immediate toxicity up to 12h and for death up to 24h. Signs of
toxicity included salivation, diarrhea, gasping, blood-stained nose discharges
and seizures. Post mortem examination showed lung hyperemia and liver
congestion. The oral acute LD50 was found to be 3.1g/kg (95%confidence limits =
1.81 – 2.95) in Wistar rats, a value 54% lower
than that reported in the literature (> 5g/kg).
KEYWORDS: Glyphosate;
N-phosphonomethylglycine; polyoxyethyleneamine;
DL50; rats; Acute toxicity; RoundupÒ .