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Online Journal of Veterinary Research©
Volume 1: 29-34, 2002.
Acute oral toxicity of glyphosate in Wistar rats.
Dallegrave Ea, Mantese FDa, Dalsenter PR,b Langeloh Aa
a Department of Pharmacology, Instituto
de Ciências Básicas da Sáude, Universidade
Dallegrave E, Mantese FD, Dalsenter PR, Langeloh A., Oral acute toxicity of glyphosate in Wistar rats, Online J Vet Res 1:29-36, 2002. The acute toxicity of glyphosate (N-phosphonomethylglycine with the surfactant polyoxyethyleneamine:Roundup®), was determined 2, 4, 6, 8, 10, 12 and 24 hours after the oral administration of 1, 2, 3 or 4g/kg to Wistar rats. Each animal was observed for immediate toxicity up to 12h and for death up to 24h. Signs of toxicity included salivation, diarrhea, gasping, blood-stained nose discharges and seizures. Post mortem examination showed lung hyperemia and liver congestion. The oral acute LD50 was found to be 3.1g/kg (95%confidence limits = 1.81 – 2.95) in Wistar rats, a value 54% lower than that reported in the literature (> 5g/kg).
KEYWORDS: Glyphosate; N-phosphonomethylglycine; polyoxyethyleneamine; DL50; rats; Acute toxicity; RoundupÒ .