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OJBTM
Online
Journal of
Bioinformatics ©
Volume
12(1):66-73, 2011
Partial sequence clone
of canine mammary tumor metalloproteinase MMP11 catalytic domain
B. V. Sunil Kumar (M.V.Sc), Meena Kataria (M.Sc,Ph.D),
G.V.P.P.S. Ravi Kumar*(M.V.Sc,Ph.D), K. Aswani Kumar (M.V.Sc)
and A.P. Vishwanatha
Reddy
Enzymology lab., Division
of Biochemistry, Indian Veterinary Research Institute, Izatnagar,
Bareilly-243122 (U.P.), India.
ABSTRACT
Sunil
Kumar BV, Kataria M, Kumar R, Kumar KA, Vishwanatha Reddy AP, Partial sequence clone of
canine
mammary tumor metalloproteinase MMP11 catalytic domain, Online J
Bioinformatics, 12(1):66-73, 2011. Partial sequence of canine MMP11
catalytic domain was cloned and sequenced (Acc o.HM037636). Nucleotide
and
translated protein sequence was close to Equus caballus
but clustered away from rodent
and primate groups. Synonymous substitution (dS)
was
higher than non-synonymous substitution (dN)
suggesting that the catalytic domain MMP11 gene was not under positive
selection and that no advantageous mutations had had any significant
role in its
evolutionary adaptation.
(Key words: Cloning, Characterization,
Matrix metalloproteinase 11, canine.