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Online Journal of Veterinary Research©
Volume 10 (1) : 75 -84, 2006
Predicted pharmacokinetic model for carbamazepine in the rabbit
Rukhadze M1,2*, Bezarashvili G1, Alexishvili M1, Fischer N3, Sebiskveradze M2, Okujava N2
1Department of Chemistry and 2Laboratory of Neurobiology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, 3HELIOS Hospital Gotha/Ohrdruf, Helios street 1, 99867 Gotha, Germany
Rukhadze M, Bezarashvili G, Alexishvili M, Fischer N, Sebiskveradze M, Okujava N. Predicted pharmacokinetic model for carbamazepine in the rabbit, Online J Vet Res, 10 (1) :75-84, 2006. Absorption (Ka) and elimination (Ke) kinetics of carbamazepine (oral) in rabbits, were determined by a successive substitution procedure combined with correlation and regression analysis. Increased dosages altered Ka and Ke considerably suggesting a step-wise absorption of carbamazepine. Kinetic equations were derived, which quantitatively describe the changes in the level of carbamazepine against time based on exponential step-wise functions. The absorption of carbamazepine at high doses is probably realized stepwise, by successive joining up of different reservoirs. The biochemical transformation of absorbed drug may occur by its interaction with enzymes. Therefore, the kinetic characteristics (rate constant, kinetic order) of biotransformation process have different values in a series of experiments. Increased doses of carbamazepine increases reservoirs and decreases the elimination kinetics from one to zero.
Key words: Experimental and predicted pharmacokinetic curves, carbamazepine, conceptual model, reservoirs, Exponential step-wise function.