©1994-2009 All
Rights Reserved. Online
Journal of Veterinary Research. You may not store these
pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is
exclusively copyrighted in its entirety to OJVR publications. This article may
be copied once but may not be, reproduced or re-transmitted without the express
permission of the editors.
OJVRTM
Online Journal of Veterinary Research©
Volume 10 (1) : 75 -84, 2006
Predicted pharmacokinetic model for carbamazepine in the rabbit
Rukhadze M1,2*, Bezarashvili G1, Alexishvili
M1, Fischer N3, Sebiskveradze M2,
Okujava N2
1Department
of Chemistry and 2Laboratory of Neurobiology, Ivane
Javakhishvili Tbilisi State University, Tbilisi,
Georgia, 3HELIOS Hospital Gotha/Ohrdruf,
Helios street 1, 99867 Gotha, Germany
Rukhadze M, Bezarashvili
G, Alexishvili M, Fischer N, Sebiskveradze M, Okujava N. Predicted
pharmacokinetic model for carbamazepine in the
rabbit, Online J Vet Res, 10
(1) :75-84, 2006.
Absorption (Ka) and elimination (Ke) kinetics of carbamazepine (oral) in rabbits,
were determined by a successive substitution procedure combined with
correlation and regression analysis. Increased dosages altered Ka and Ke considerably suggesting a step-wise absorption of carbamazepine. Kinetic equations were derived, which
quantitatively describe the changes in the level of carbamazepine
against time based on exponential step-wise functions. The absorption of carbamazepine at high doses is probably realized stepwise,
by successive joining up of different reservoirs. The biochemical
transformation of absorbed drug may occur by its interaction with enzymes.
Therefore, the kinetic characteristics (rate constant, kinetic order) of
biotransformation process have different values in a series of experiments. Increased doses of carbamazepine
increases reservoirs and decreases the elimination kinetics from one to
zero.
Key words: Experimental and
predicted pharmacokinetic curves, carbamazepine,
conceptual model, reservoirs, Exponential step-wise function.