©1996-2009 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Bioinformatics©
Volume 9 (1): 12-20, 2008
Elucidating the role of CREBBP co-activator in erythroid differentiation by literature mining and analysis
Iyer J1*, Raghunath A1, Bhate J1 and Wong.L2
1 Molecular Connections Pvt. Ltd, Kandala Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India and 2National Institute of Singapore, Science Drive 2, Singapore 117543, Republic of Singapore
Iyer J, Raghunath A, Bhate J, Wong L., Elucidating the role of CREBBP co-activator in erythroid differentiation by literature mining and analysis, Online J Bioinformatics 9 (1): 12-20, 2008. Differentiation of pluripotent hematopoietic stem cells into mature circulating erythrocytes are coordinated by a set of lineage- and tissue specific transcription factors. The two highly related nuclear proteins CREB binding protein (CBP or CREBBP) and p300 are co-activators that possess histone acetyltransferase activity, play a central role in the integration of transcription signals involving diverse cellular processes and differentiation pathways such as hematopoiesis, embryogenesis and so .We have been using literature mining successfully to unravel various biological processes and provide a concise view of regulation of the physiological networks. An interaction database NetProTM was used as a source of all interactions in this study. By further network analysis, CBP is shown as a molecular integrator of hematopoietic differentiation. Several transcription factor nodes through which the master regulatory cofactor CBP binds and modulates the expression or activity of downstream genes involved in erythrocyte differentiation have been elucidated.
Key words: CBP, CREBBP, erythrocyte differentiation, transcription factor network, literature mining