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OJBTM
Online Journal of Bioinformatics ©
Volume
11 (2): 245-263, 2010
Target sites for microRNA expressed in pancreatic islets
in Type 2 diabetes mellitus associated genes.
Manika Pal-Bhadra1, Neelima
Arora2, Shinde Santosh
P2, Paramita Ray1, Amit Kumar Banerjee1, Venkateswara
Rao Sripathi3
1 Centre for
Chemical Biology and Biology Division, Indian Institute of Chemical Technology
(IICT), and 2Functional Genomics and Gene Silencing Group, Centre
for Cellular and Molecular Biology (CCMB), Hyderabad, India.3 NRES, Department
of Natural Resources and Environmental Sciences. Alabama A & M University, Normal, USA.
ABSTRACT
Pal-Bhadra M, Arora N, Santosh S, Ray P, Banerjee AK,
Sripathi VR, Murty USN, Bhadra Uci O.,Target sites
for microRNA expressed in pancreatic islets in Type 2
diabetes mellitus associated genes, Online J Bioinformatics, 11 (2): 245-263,
2010. In
Type 2 diabetes mellitus (T2DM) associated genes, regulation of insulin secretion and glucose homeostasis
is mediated by regulatory microRNAs. Thirty genes are
known to be involved in metabolic pathways, operating in Type 2 diabetes
mellitus (T2DM). MiRanda
(1.0) was employed to predict target sites for microRNA
expressed in pancreatic islets in T2DM associated genes. Target sites predicted
by miRanda in 3’ UTR were
compared with predictions of TargetScan and PicTar. Ten miRNAs
targeting the genes were identified.
Keywords: Type
2 Diabetes mellitus, miRNA, miRANDA, , target site prediction