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Online Journal of Bioinformatics©
Volume 8 (1):61-73, 2007
In Silico identification of antioxidant gene G6PD in Caenorhabditis elegans
Jitendra N, Prachi S, Alpana V, Shakti S
Bioinformatics Centre, AIB, Amity University, Noida, UP, INDIA
Jitendra N, Prachi S, Alpana V, Shakti S., In silico identification of Antioxidant gene G6PD in Caenorhabditis elegans, Online J Bioinformatics 8 (1) : 61-73, 2007. Interest in C. elegans as a target for drug discovery has grown considerably, particularly in the pharmaceutical and agro-chemical industries. C. elegans is a proven model system for investigating numerous neurodegenerative diseases and physiological processes. Several neurodegenerative disorders have been modeled in C. elegans including Huntingtonís disease, Alzheimerís disease, Parkinsonís disease, and cancer. C.elegans models are also used for antioxidant screens, diabetes, and determining alterations in gene expression. In humans there are 81 genes known to have antioxidant properties with 60% similarities in the genome of Caenorhabditis elegans with Homo sapiens, but only five genes Prdx-2 Prdx-3, clk-2, clk-1 and gro-1, show antioxidant properties in Caenorhabditis elegans. These findings suggest that other unknown genes of Caenorhabditis elegans may have antioxidant properties. A BLAST of known antioxidant gene in Homo sapiens with the genome of Caenorhabditis elegans identified a locus in Caenorhabditis elegans contig named B0035 that showed good homology with G6PD gene in Homo sapiens geneID 2539 present on chromosome number X located at Xq28.
KEY WORDS: Antioxidant, Caenorhabditis elegans, BLAST, G6PD gene, Contig