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Online Journal of Veterinary Research©
Volume 13 (2):114-119, 2009
Genetic and antigenic relationship between foot and mouth disease
virus serotype Asia-1 isolate and vaccine strain
Department of Epidemiology and Veterinary Preventive Medicine, Mathura, India
Ul Islam MR, Kumar Verma A, Yadav SK, Pal Mahima BC, Jain U, Genetic and antigenic relationship between foot and mouth disease virus serotype Asia-1 isolate and vaccine strain, Online J Vet Res 13 (2):114-119, 2009. Partial nucleotide sequence of capsid polypeptide coding gene 1D (VP-1 coding) of FMD virus serotype Asia-1 isolate (IND121/09) recovered from recent outbreak in Uttar Pradesh, India was determined. Phylogenetic comparison of this isolate was done with some of the previously published sequences and vaccine strain IND63/72. The isolate clustered in lineage C and subcluster CI. Comparison of amino acid sequences identified lineage-specific residues in the structural protein. Although a considerable genetic variation was observed in the isolate of present study, yet in micro-neutralization test it was serologically related to the vaccine strain.
KEY WORDS: Foot and Mouth Disease serotype Asia-1, Genetic analysis, Phylogenetic analysis.