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OJVR
Online Journal of Veterinary Research©
Volume 13 (2):114-119, 2009
Genetic and antigenic relationship between
foot and mouth disease
virus serotype Asia-1 isolate and vaccine strain
Department of Epidemiology and Veterinary Preventive Medicine, Mathura, India
ABSTRACT
Ul Islam MR, Kumar Verma
A, Yadav SK, Pal Mahima
BC, Jain U, Genetic and antigenic relationship
between foot and mouth disease virus serotype Asia-1 isolate and vaccine
strain, Online J Vet Res 13 (2):114-119, 2009. Partial nucleotide sequence of capsid polypeptide coding gene 1D (VP-1 coding) of FMD
virus serotype Asia-1 isolate (IND121/09) recovered from recent outbreak in
Uttar Pradesh, India was determined. Phylogenetic
comparison of this isolate was done with some of the previously published
sequences and vaccine strain IND63/72. The isolate clustered in lineage C
and subcluster CI. Comparison of amino acid sequences
identified lineage-specific residues in the structural protein. Although a
considerable genetic variation was observed in the isolate of present study,
yet in micro-neutralization test it was serologically related to the vaccine
strain.
KEY WORDS: Foot and Mouth Disease serotype
Asia-1, Genetic analysis, Phylogenetic analysis.