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OJPTM
Online Journal
of Pharmacology
(and Pharmacokinetics)©
Volume 7: 31-34, 2011
Pharmacokinetics of Gentamicin in
buffalo calves after IV administration
Sushma Lalita Baxla1, C.Jayachandran2, Birendra Kumar Roy3, Ravuri
Halley Gora3
Sushma Lalita Baxla1, C.Jayachandran2, Birendra Kumar Roy3, Ravuri
Halley Gora 3Dept.
of Veterinary Pharmacology & Toxicology, College of Veterinary Science
& A. H., 2Bihar Veterinary College Patna, 3Birsa Agricultural University,
Ranchi, India.
ABSTRACT
Baxla SL, Jayachandran
C, Roy BK, Gora RH., Pharmacokinetics of Gentamicin
in buffalo calves after IV administration, Online J Pharmacol,
7: 31-34,
2011. The disposition kinetics of gentamicin
was determined after single dose of 5mg/kg IV administration in 5 buffalo
calves. The mean peak plasma
concentration of 19.80 ± 1.36µg/ml occurred at 0.042h. The drug was detected up
to 24 h with a mean concentration of 0.023 ± 0.03µg/ml. The mean therapeutic
concentration of gentamicin (≥ 2 µg/ml) was
maintained up to 6 h in plasma. In urine, gentamycin
was detected for more than 48 h with a mean peak of 83.42 ± 3.17 µg/ml 1.5h and
a mean therapeutic concentration ≥ 2 µg/ml lasting 24h. The distribution rate constant and
distribution half life were 1.058 ± 0.100h-1 and 0.69 ± 0.08 h-1
respectively, suggesting a rapid distribution. The elimination rate constant
and elimination half life of 0.139 ± 0.008h-1 and 5.05 ± 0.30h-1
respectively indicated that the drug was eliminated slowly at 0.351 ± 0.023h-1
with a total body clearance of 1.86 ± 0.16ml/kg/min from the central
compartment. This led to a high mean residential time of 5.79 ± 0.34h-1
indicating that this antibiotic remained for a longer period in the body of
buffalo calves. The high Vdarea of 0.80 ±
0.04L/kg was supported by a tissue to plasma concentration of 1.54 ± 0.16.
Key
words: Pharmacokinetics, gentamicin,
buffalo calves, intravenous.