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OJVRTM
Online Journal of Veterinary
Research©
Volume 12 (1) :46-50, 2008
Effects of vitamin C on ketamine-diazepam
anesthesia in dogs
Marjani M1, Selk Ghaffari M1, Bahonar AR2,
Yazdanpanah Abdolmaleki A1.
1Department of Clinical sciences,
Faculty of Veterinary Medicine, Islamic Azad
University-Karaj Branch.
ABSTRACT
Marjani M, Selk Ghaffari M, Bahonar AR, Yazdanpanah Abdolmaleki A., Effects of vitamin C on ketamine-diazepam anesthesia in dogs, Online J Vet Res, 12 (1) :46-50, 2008. The
effect of pre-anesthetic administration of vitamin C on general anesthesia with
ketamine-diazepam was evaluated in dogs. A total of
20 dogs were divided into four groups of five. In this study; heart rate,
respiratory rate, duration of anesthesia, body temperature, blood glucose, and
calcium were evaluated before and following induction
of anesthesia. Group one received only 4 ml of sterile intravenous
saline. Dogs in group two anesthetized by intravenous ketamine-diazepam. Two treatment
groups; group three and four were premedicated with
100 mg and 500 mg vitamin C respectively, 30 minutes before induction of
general anesthesia by intravenous ketamine-diazepam
combination. In comparison to group two, significant increase was observed in
body temperature of dogs in group three and four. There was a significant
increase in blood glucose level in both treatment groups (group three and
four). The mean ± SD duration of anesthesia was significantly longer in group
two (41.8 ± 2.8 minutes) than group three (22.6 ± 2.5 minutes) and group four
(23.2 ± 2.03 minutes). In conclusion, it seems that pre-medication with vitamin
C, may be useful in animals suffering from pre-surgical hypothermia,
hypoglycemia, and in dogs who are suspected to be in a risk during prolonged
anesthesia.
Key words:
vitamin C, ketamine, diazepam, anesthesia, dog
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