©1996-2012 All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety toOJVR.This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Veterinary Research©
Volume 16 (3):138-146, 2012.
Evaluation of Glycyrrhiza glabra (Licorice) on wound healing in rats
Aboutorab Tabatabaei Naeini1, Ahmad Oryan2, Behrooz Nikahval1, Mahvash Toosinezhad
1Department(s) of Surgery and Radiology, and 2Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Naeini AT, Oryan A, NikahvalB, Toosinezhad M., Evaluation of Glycyrrhiza glabra (Licorice) on wound healing in rats, Online J Vet Res., 16 (3):138-146, 2012. Glycyrrhiza glabra (Licorice) has been shown to have beneficial effects on healing. The present study was conducted to evaluate the effects of Licorice Root Powder (LRP) on cutaneous wound healing. After aseptic surgical preparations, identical (2×2cm) full thickness wounds were created in the skin of the dorsal cervical region of 10 rats and 10 untreated control rats. Treated rats were given LPR topically daily and rinsed with sterile saline after for 5 days. Wounds were observed for 21 days and then rats were euthanized. The rate of wound healing was determined planimetrically at day 0, 5, 10, 15 and 20. Histology revealed differences in re-epithelialization, inflammatory cell infiltration and tissue organization. Stiffness and ultimate strength of wounds treated with LPR were greater than untreated ones. It was concluded that LRP reduced number of inflammatory cells, and enhanced fibroblasts maturation and tissue alignment.
Keywords: Licorice powder, Wound healing, Cutaneous, rat