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OJVRTM
Online Journal of Veterinary Research©
Volume 16 (3):138-146, 2012.
Evaluation of Glycyrrhiza glabra (Licorice)
on wound healing in rats
Aboutorab Tabatabaei Naeini1,
Ahmad Oryan2, Behrooz Nikahval1,
Mahvash Toosinezhad
1Department(s)
of Surgery and Radiology, and 2Pathobiology, School of
Veterinary Medicine, Shiraz University, Shiraz, Iran.
ABSTRACT
Naeini AT, Oryan A, NikahvalB, Toosinezhad M.,
Evaluation of Glycyrrhiza glabra (Licorice) on wound healing in rats,
Online J Vet Res., 16 (3):138-146, 2012. Glycyrrhiza glabra (Licorice) has been shown to have beneficial
effects on healing. The present study was conducted to evaluate the effects of
Licorice Root Powder (LRP) on cutaneous wound
healing. After aseptic surgical preparations, identical (2×2cm) full
thickness wounds were created in the skin of the dorsal cervical region of 10
rats and 10 untreated control rats. Treated rats were given LPR topically daily
and rinsed with sterile saline after for 5 days. Wounds were observed for 21
days and then rats were euthanized. The rate
of wound healing was determined planimetrically at
day 0, 5, 10, 15 and 20. Histology revealed differences in re-epithelialization, inflammatory cell infiltration and
tissue organization. Stiffness and ultimate strength of wounds treated with LPR
were greater than untreated ones. It was concluded that LRP reduced number of
inflammatory cells, and enhanced fibroblasts maturation and tissue alignment.
Keywords: Licorice powder, Wound healing, Cutaneous, rat