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OJVR
Online Journal of Veterinary Research©
Volume
13 (2):128-135, 2009
Respiratory macrophage activity and pulmonary
morphology following
exposure to
benzo(a)pyrene in broilers
Latif IK1 (DVM, MS),
Karim AJ1 (DVM, MS), Zuki ABZ1
(DVM, PhD), Zamri-Saad
M1 (DVM, PhD, Niu
JP2 (MD, MS), Noordin MM1 (DVM,
MS, PhD)
1Faculty of
Veterinary Medicine, Universiti Putra Malaysia, 43400
Serdang, Selangor, Malaysia,2School of
Public Health, Lanzhou University, 73000 Lanzhou, China
ABSTRACT
Latif
IK, Karim AJ, Zuki ABZ, Zamri-Saad M, Niu JP, Noordin MM, Respiratory macrophage activity and pulmonary
morphology following exposure to benzo(a)pyrene in broilers, Online J Vet Res, 12 (2):128-135, 2009.
The effect of benzo(a)pyrene
(BaP) on the macrophage defense system and lung morphology
in broilers was
evaluated. One day age chicks were
divided into 4 groups of 40. Control chicks were given tricaprylin
alone intratracheally (IT), while treated groups were
given BaP (viz, at 1.5μg, 150μg or 15mg/kg bodyweight) for 5 consecutive days IT. Ten
birds per group were sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed immediately to procure avian
respiratory macrophages (ARM). A significant decrease in the mean values of the
given lavage volume, phagocytosis
and intracellular killing activities along with an increase in ARM counts was
observed especially in the group receiving 15mg BaP, suggesting a possible immunopulmonary
toxic effect of inhaled BaP.
Keywords: benzo(a)pyrene, intra-tracheal, macrophage, toxicity, broiler