©1994-2009 All Rights Reserved. Online Journal
of Veterinary Research. You may not store these pages in any form except
for your own personal use. All other usage or distribution is illegal under
international copyright treaties. Permission to use any of
these pages in any other way besides the before mentioned must be gained in
writing from the publisher. This article is exclusively copyrighted in
its entirety to OJVR publications. This article may be copied once but may not
be, reproduced or re-transmitted without the express permission of the editors.
OJVRTM
Online Journal of Veterinary Research©
Volume 7
: 91-98, 2003.
Effect of sub-acute
doses of Maduramycin in broiler chicks
Arun KHS1, Manjunath HS*,
Reddy KS, Reddy R, Kalakumar B.
Department of Pharmacology and Toxicology,
ABSTRACT:
Arun KHS, Manjunath
HS, Reddy KS, Reddy R, Kalakumar B. Effect of sub-acute doses of Maduramycin
in Broiler Chicks. Online Journal of Veterinary Research 7: 91-98, 2003. The effects of 5 and 8-ppm oral maduramycin
(in feed), in broiler chicks was evaluated over 6 weeks. Toxic signs included
in-coordination, lethargy, leg weakness, diarrhea, reduced feed intake and
weight loss. Sternal recumbency
with neck, wings and hind limbs outstretched were characteristic and prominent
by the 4th week. Extensive pathological lesions were observed in skeletal
muscle, heart, lungs, kidney, liver, intestines and bursa. Serum alanine aminotransferase, aspartate aminotransferase,
alkaline phosphatase and lactase dehydrogenase
activity and urea, creatinine and cholesterol levels
increased whereas total protein, albumin and globulin levels decreased.
Hematological studies revealed severe macrocytic hypochromic anemia. There were no significant changes in
the parameters measured in control 5-ppm maduramycin
fed birds. Our results for the first time report an extensive change in
biochemical profiles observed with maduramycin
toxicity, suggesting the pathology is ubiquitous. In addition for the first
time we report vascular toxicity of maduramycin as
evident from the extensive hemorrhages observed in all the organs studied.
Hence, we emphasize the need for adequate care while mixing maduramycin
in feed to ensure its appropriate levels and avoid using feeds stored for long
time without its proper mixing prior to use.
KEY-WORDS: Maduramycin,
biochemical parameters, broiler chicks and subacute
toxicity.
©1994-2003 All Rights Reserved. Online Journal
of Veterinary Research. You may not store these pages in any form except
for your own personal use. All other usage or distribution is illegal under
international copyright treaties. Permission to use any of
these pages in any other way besides the before mentioned must be gained in
writing from the publisher. This article is exclusively copyrighted in
its entirety to OJVR publications. This article may be copied once but may not
be, reproduced or re-transmitted without the express permission of the editors.