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Online Journal of Bioinformaticsâ
Volume 5 : 1-12, 2004
Molecular phylogenetics and functional evolution of major RNA recognition domains of recently cloned and characterized autoimmune RNA-binding particle.
Institute of Biochemistry, University of Vienna, Medical Faculty, Vienna Biocenter, Dr. Bohr-Gasse 9/3, A-1030, Vienna, Austria
Suleymanoglu E Molecular phylogenetics and functional evolution of major RNA recognition domains of recently cloned and characterized autoimmune RNA-binding particle Online J Bioinformatics 5: 1-12, 2004 Heterogeneous nuclear ribonucleoproteins (hnRNPs) are spliceosomal macromolecular assemblages and thus actively participate in pre-mRNA metabolism. They are composed of evolutionarily conserved tandemly repeated motivs, where both RNA-binding and protein-protein recognition occur to achieve cellular activities. By yet unknown mechanisms these ribonucleoprotein particles are targeted by autoantibodies and hence play significant role in variety of human systemic autoimmune diseases. This feature makes them important prognostic markers in terms of molecular epidemiology and pathogenesis of autoimmunity. Since ribonucleoprotein (RNP) domain is one of the most conserved and widespread scaffolds, evolutionary analyses of these RNA-binding domains can provide further clues on disease-specific epitope formation. The study presented herein represents a sequence comparison of RNA-recognition regions of recently cloned and characterized human hnRNP A3 with those of other relevant hnRNP A/B-type proteins. Their implications in human autoimmunity is particularly emphasized.
KEY WORDS: hnRNP proteins, RNA folding, RNA-protein interactions