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OJVR
Online Journal of Veterinary Research©
Volume 13 (2):65-72, 2009
Effect of intranasal
attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
Khin MN1, Zamri-Saad
M1, Noordin MM1, Effendy AWM2
1Faculty of
Veterinary Medicine, Universiti Putra, 2Faculty
of Science and Technology, Universiti Malaysia
Terengganu, Malaysia.
ABSTRACT
Khin MN, Zamri-Saad M, Noordin MM, Effendy AWM., Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online J Vet Res., 13 (2):65-72, 2009. This report describes the effect of vaccination with
attenuated P. multocida
B:2 on wild-type P. multocida B:2 infection in calves. Calves
were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves
were then mingled with the vaccinated Group. Control untreated calves were kept
separate. After 6 weeks, all calves were challenged intra-tracheally
with 107 CFU/mL
of live wild-type P. multocida
B:2. At Post-Mortem none of the vaccinated or mingled
calves had lesions whereas controls revealed pulmonary petechial
haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed
significantly (p<0.05) higher levels of serum IgG.
P. multocida B:2 were successfully isolated only from the control calves
of Group 3. These findings suggest that intranasal exposures to live attenuated
P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected
susceptible calves.
Keywords:
Intranasal,
attenuated Pasteurella multocida B:2, infection