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OJVRTM
Online Journal of Veterinary Research©
Volume 9 (1): 37-47, 2005
Comparison of the
effects of lindane and permethrin
on
pentylenetetrazole-induced
clonic seizure in mice
Samini M, Shafarood H, Sehat V, Allahdini S., Comparison
of the effects of lindane and permethrin
on pentylenetetrazole-induced clonic
seizure in mice, Online J Vet Res 9(1) : 37-47, 2005. The effects of lindane and
permethrin, antagonists of the GABAA
receptor/chloride channel complex, on pentylenetetrazole-induced
clonic seizure threshold were compared in mice. In
controls, seizure threshold of pentylenetetrazole
(PTZ) was 35.2+9+0.56 mg/kg. In pre-treated mice with clonazepam or ivermectin,
agonists of the GABAA receptor/chloride channel complex, a
dose-dependent increase in the amount of PTZ that was needed to induce a
seizure was observed. In pre-treated animals with lindane
or permethrin, the PTZ-induced seizure threshold
decreased to 28.10+0.70 and 22.90++0.80 mg/kg, respectively.
Pre-treatment of mice with lindane or permethrin antagonized the effects of clonazepam
and ivermectin on PTZ-induced seizure threshold. The
results suggest that increasing the PTZ-induced threshold with clonazepam and ivermectin may be
due to a competition between GABAA agonist and PTZ as GABAA
antagonist. Decreasing the PTZ-induced threshold with lindane
and permethrin may be due to additive antagonistic
effects of PTZ and these agents on GABAA receptor. Decreasing the
agonistic effects of clonazepam and ivermectin on PTZ-induced seizure with lindane
and permethrin may show a competition between these
agonists and antagonists on GABAA receptor. Lindane
also was more powerful convulsant than permethrin.
KEYWORDS: Lindane, Permethrin, Ivermectin, Clonazepam, PTZ, Clonic seizure