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Online Journal of Veterinary Research©
Volume 9 (1): 37-47, 2005
Comparison of the effects of lindane and permethrin on
pentylenetetrazole-induced clonic seizure in mice
Samini M, Shafarood H, Sehat V, Allahdini S., Comparison of the effects of lindane and permethrin on pentylenetetrazole-induced clonic seizure in mice, Online J Vet Res 9(1) : 37-47, 2005. The effects of lindane and permethrin, antagonists of the GABAA receptor/chloride channel complex, on pentylenetetrazole-induced clonic seizure threshold were compared in mice. In controls, seizure threshold of pentylenetetrazole (PTZ) was 35.2+9+0.56 mg/kg. In pre-treated mice with clonazepam or ivermectin, agonists of the GABAA receptor/chloride channel complex, a dose-dependent increase in the amount of PTZ that was needed to induce a seizure was observed. In pre-treated animals with lindane or permethrin, the PTZ-induced seizure threshold decreased to 28.10+0.70 and 22.90++0.80 mg/kg, respectively. Pre-treatment of mice with lindane or permethrin antagonized the effects of clonazepam and ivermectin on PTZ-induced seizure threshold. The results suggest that increasing the PTZ-induced threshold with clonazepam and ivermectin may be due to a competition between GABAA agonist and PTZ as GABAA antagonist. Decreasing the PTZ-induced threshold with lindane and permethrin may be due to additive antagonistic effects of PTZ and these agents on GABAA receptor. Decreasing the agonistic effects of clonazepam and ivermectin on PTZ-induced seizure with lindane and permethrin may show a competition between these agonists and antagonists on GABAA receptor. Lindane also was more powerful convulsant than permethrin.
KEYWORDS: Lindane, Permethrin, Ivermectin, Clonazepam, PTZ, Clonic seizure