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OJVR
Online Journal of Veterinary Research©
Volume
13 (2):72-83, 2009
Effects of acetylcysteine and dexamethasone on intraocular
pressure and pupil diameter in normal dogs
Sarchahi AA, DVM, PhD, and Harrazi A, DVM.
Department of Veterinary Clinical Studies, School
of Veterinary Medicine, Shiraz University
ABSTRACT
Sarchahi AA, Harrazi A. Effects of acetylcysteine and dexamethasone on intraocular pressure and pupil diameter in
normal dogs, Online J Vet Res., 13
(2):72-83, 2009. This study
was designed to evaluate whether acetylcysteine alone
and in association with dexamethasone could reduce
the intraocular pressure (IOP) in normal dogs. Three groups of five dogs each
were administered in the right eye, one drop of 3% acetylcysteine
(NAC), 0.1% dexamethasone (DEXA), and 3% acetylcysteine with 0.1% dexamethasone
(NACDEXA), respectively. Mean IOP in dogs given DEXA and NAC+DEXA increased compared
to the saline treated left eye whereas in those given NAC, did not. There were no significant differences between
the mean IOP’s of eyes treated with DEXA or NAC+DEXA but IOP was higher compared
to animals given NAC. NAC and DEXA nor their combination had any effect on pupil
diameter. The results suggest that acetylcysteine could
be used in glaucomatous conditions. However the administration of acetylcysteine with dexamethasone
may increase the intraocular pressure in normal and glaucomatous dogs.
Key words: Acetylcysteine, Dexamethasone, Dog, Intraocular pressure, Pupil diameter .