©1994-2009 All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under International copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editor
Online Journal of Veterinary Research©
Volume 13 (2):72-83, 2009
Effects of acetylcysteine and dexamethasone on intraocular pressure and pupil diameter in normal dogs
Sarchahi AA, DVM, PhD, and Harrazi A, DVM.
Department of Veterinary Clinical Studies, School of Veterinary Medicine, Shiraz University
Sarchahi AA, Harrazi A. Effects of acetylcysteine and dexamethasone on intraocular pressure and pupil diameter in normal dogs, Online J Vet Res., 13 (2):72-83, 2009. This study was designed to evaluate whether acetylcysteine alone and in association with dexamethasone could reduce the intraocular pressure (IOP) in normal dogs. Three groups of five dogs each were administered in the right eye, one drop of 3% acetylcysteine (NAC), 0.1% dexamethasone (DEXA), and 3% acetylcysteine with 0.1% dexamethasone (NACDEXA), respectively. Mean IOP in dogs given DEXA and NAC+DEXA increased compared to the saline treated left eye whereas in those given NAC, did not.† There were no significant differences between the mean IOPís of eyes treated with DEXA or NAC+DEXA but IOP was higher compared to animals given NAC. NAC and DEXA nor their combination had any effect on pupil diameter. The results suggest that acetylcysteine could be used in glaucomatous conditions. However the administration of acetylcysteine with dexamethasone may increase the intraocular pressure in normal and glaucomatous dogs.
Key words: Acetylcysteine, Dexamethasone, Dog, Intraocular pressure, Pupil diameter .