©1994-2007
All Rights Reserved. Online Journal of Veterinary Research.
You may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR publications. This
article may be copied once but may not be, reproduced or re-transmitted without
the express permission of the editors
OJVRTM
Online Journal of Veterinary Research©
Volume
11(2):38-44, 2007
Phenyl phosphorodiamidate
(PPD) adversely affects the
electrophysiology of the rumen epithelium in Sheep
Abdoun K1, Martens
H2
1Department of
Physiology, Faculty of Veterinary Medicine, University of Khartoum, 13314 Shambat, Sudan 2Institute of Veterinary
Physiology, Faculty of Veterinary Medicine, Free University of Berlin, Oertzenweg 19b, 14163 Berlin, Germany
ABSTRACT
Abdoun K, Martens H,
Phenyl phosphorodiamidate
(PPD) adversely affects the electrophysiology of the rumen epithelium in Sheep,
Online J Vet Res 11(2):38-44, 2007.
The effect of mucosal
application of 1mmol/l phenyl phosphorodiamidate
(PPD) on the electrophysiology of isolated rumen epithelium was studied in vitro using a conventional Ussing chamber technique. Thirty-six isolated rumen epithelium
samples from 5 sheep of different breeds, age and sex and solely fed on hay
were used. Mucosal application of phenyl phosphorodiamidate,
which has an application in improving the utilization of dietary urea in
ruminants nutrition, on the mucosal side of ruminal
epithelial tissues resulted in a significant (p<0.05) reduction of the transepithelial potential difference (PDt)
and epithelial short circuit current (Isc), and a
significant (p<0.05) elevation of the epithelial tissue conductance (Gt).
Phenyl phosphorodiamidate could thus impair the
barrier and transport function of the rumen epithelium.
KEY-WORDS: Electrophysiology; Phenyl phosphorodiamidate; Rumen; Sheep
BACK TO MAIN
PAGE