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Online Journal of Veterinary Research©
Volume 7:33-42, 2003.
Sub-acute oral toxicity of Salinomycin
in broiler chicks
Arun KHS, Manjunath HS, Reddy KS, Reddy R.
Department of Pharmacology and Toxicology, College of Veterinary Science, ANGRAU, Rajendranagar, Hyderabad, Cardiovascular & Endocrinology Lab, Dept of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research, Phase X, Mohali, Punjab, Dept of LPM. Biochemist, Biocon India Ltd., Bangalore, India.
Arun KHS, Manjunath HS, Reddy KS, Reddy R., Sub-acute oral toxicity of Salinomycin in broiler chicks, Online J Vet Res 7:33-42, 2003. The effects of 120 ppm salinomycin in feed (sub-acute oral toxicity) on clinical signs, tissue and serum biochemistry of broiler chicks was evaluated. Symptoms included in-coordination, lethargy, leg weakness, diarrhea, reduced feed intake and weight loss. Sternal recumbency with neck, wings and extended hind limbs were characteristic and prominent by the 4th week of salinomycin exposure. Extensive lesions were found in skeletal muscle, heart, lungs, kidney, liver, intestines and bursa. Serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactase dehydogenase, urea, creatinine and cholesterol increased whereas total protein, albumin and globulin decreased. There were no significant changes in values taken from control birds or those fed 60 ppm salinomycin.
KEY WORDS: Salinomycin, toxicity, broilers.