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OJVRTM
Online Journal of Veterinary Research©
Volume 7:33-42, 2003.
Sub-acute oral toxicity of Salinomycin
in broiler chicks
Arun KHS, Manjunath HS, Reddy
KS, Reddy R.
Department of
Pharmacology and Toxicology, College of Veterinary Science, ANGRAU, Rajendranagar, Hyderabad, Cardiovascular & Endocrinology Lab, Dept
of Pharmacology & Toxicology, National Institute of Pharmaceutical
Education & Research, Phase X, Mohali, Punjab,
Dept of LPM. Biochemist, Biocon India Ltd.,
Bangalore, India.
SUMMARY
Arun KHS, Manjunath
HS, Reddy KS, Reddy R., Sub-acute oral toxicity of Salinomycin
in broiler chicks, Online J Vet Res 7:33-42, 2003. The effects
of 120 ppm salinomycin in
feed (sub-acute oral toxicity) on clinical signs, tissue and serum biochemistry
of broiler chicks was evaluated. Symptoms included in-coordination, lethargy,
leg weakness, diarrhea, reduced feed intake and weight loss. Sternal recumbency with neck,
wings and extended hind limbs were characteristic and prominent by the 4th week
of salinomycin exposure. Extensive lesions were found
in skeletal muscle, heart, lungs, kidney, liver, intestines and bursa. Serum alanine aminotransferase, aspartate aminotransferase,
alkaline phosphatase and lactase dehydogenase,
urea, creatinine and cholesterol increased whereas
total protein, albumin and globulin decreased. There were no significant
changes in values taken from control birds or those fed 60 ppm
salinomycin.
KEY WORDS: Salinomycin,
toxicity, broilers.