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OJVRTM
Online Journal of Veterinary Research©
Volume
13 (1):26-31, 2009
LD50
of salinomycin in laying and broiler chickens with or
without oral phenobarbital and chloramphenicol
Rajaian Ha, Nazifi
Sb* , Aberumandi Ma,
Jalaei Ja
aDepartments of Pharmacology and bClinical
Pathology,
ABSTRACT
Rajaian H, Nazifi S, Aberumandi M, Jalaei J., LD50
of salinomycin in laying and broiler chickens with or
without oral phenobarbital and chloramphenicol,
Online J Vet Res, 13
(1) :26-31, 2009. The
LD50 of salinomycin with or without oral phenobarbital and chloramphenicol
was determined in laying and broiler hens. The LD50 of salinomycin in broiler chickens and laying hens was 108 and
104 mg/kg body weight, respectively. Mortality decreased about 9% in layers
given chloromphenicol or phenobarbital, 15% in broilers
given chloramphenicol but 32% in broiler hens given phenobarbital. There were no significant changes in
biochemical parameters due to salinomycin in any
group. The LD50 of salinomycin in this
study was similar to those reported previously. The lowering of the death rate
by phenobarbital in broiler chickens receiving LD50
dose of salinomycin was probably due to the inducing
effect of phenobarbital on the liver microsomal enzymes by modifying xenobiotic
metabolism.
Key words: Salinomycin, LD50, Chickens, Chloramphenicol, Phenobarbital