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Online Journal of Veterinary Research©
Volume 8:7-15, 2004.
1 Department of Laboratory Animal Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814-4799, 2 Veterinary Medicine and Surgery Branch USAMRICD, 3100 Ricketts Point Rd, APG, MD 21005 3Veterinary Medicine Division USAMRIID, 1425 Porter Street, Ft. Detrick, Md 21702, and 4 U.S. Food and Drug Administration Center for Devices and Radiological Health Office of Science and Technology, 9200 Corporate Blvd. (HFZ-100), Rockville MD 20850 * Corresponding Author: Veterinary Medical Division USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702
Murray LE, Dalal SJ, Rico PJ, Chenault .M, Evaluation of The Estrous Cycle in the Sand Rat, (Psammomys obesus), an Animal Model of Nutritionally Induced Diabetes Mellitus, Online J Vet Res 8:106-111, 2004. Psammomys obesus or the fat sand rat is a wild desert rodent in the gerbil family. This animal is unique in that it develops mild to moderate obesity, hyperglycemia and the complications of diabetes such as cataracts, pancreatic atrophy, impaired renal function and ketoacidosis by dietary induction. The sand rat is a nutritionally induced animal model for Non-Insulin- Dependent Diabetes Mellitus (NIDDM). Complications from diabetic mellitus in people such as blindness due to cataracts, kidney disease, delayed wound healing and cardiovascular disease can be studied using the sand rat as a model. Information regarding the estrous cycle in the sand rat is limited. In this experiment, a comparison between low calorie sand rat chow verses high calorie rodent chow diets were compared with respect to dietary effects on estrous cycle length. Information leading to a better understanding of the reproductive cycle and whether low calorie or high calorie diets will influence the cycle are important to researchers who must maintain breeding colonies. We found the average length of the estrous cycle to be 4.0±0.9 days for normal and 4.8±0.7 days for diabetogenic sand rats.
KEY WORDS: Sand Rat, Diabetes, Estrous Cycle