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OJVRTM
Online Journal of Veterinary Research ©
Volume 14 (2): 227-232, 2010
Identification of single nucleotide variations
in CYP1A1 gene in repeat breeding
cattle
Thanislass J1,
Ph.D., and Lydia Dhanammal2, Ph.D.,
1Department of
Veterinary Biochemistry, 2Department
of Animal Genetics and Breeding, Rajiv Gandhi College of Veterinary and Animal
Sciences, Pondicherry-605009, India
ABSTRACT
Thanislass J, Dhanammal L., Identification of single nucleotide
variations in CYP1A1 gene in repeat breeding cattle, Online J Vet Res, 14 (2):
227-232, 2010. CYP1A1
gene may affect hydroxylation of estrogen and thus, repeat breeding in cattle. Ten
normal and 20 repeat breeder Bos indicus were used to determine nucleotide transitions
from T à C and from Aà G in Exon
7 of the CYP1A1 gene. Transitions found
were non-synonymous single nucleotide polymorphisms resulting in amino acid change
from Tyrosine to Histidine and Isoleucine
to Valine, respectively. This transition in cattle may
affect estrogen and thus, the repeat breeding syndrome.
Key
Words: CYP1A1, SNP, Repeat Breeding,
ASPCR, Estrogen