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Online Journal of Veterinary Research ©
Volume 14 (2): 227-232, 2010
Identification of single nucleotide variations in CYP1A1 gene in repeat breeding cattle
Thanislass J1, Ph.D., and Lydia Dhanammal2, Ph.D.,
1Department of Veterinary Biochemistry, 2Department of Animal Genetics and Breeding, Rajiv Gandhi College of Veterinary and Animal Sciences, Pondicherry-605009, India
Thanislass J, Dhanammal L., Identification of single nucleotide variations in CYP1A1 gene in repeat breeding cattle, Online J Vet Res, 14 (2): 227-232, 2010. CYP1A1 gene may affect hydroxylation of estrogen and thus, repeat breeding in cattle. Ten normal and 20 repeat breeder Bos indicus were used to determine nucleotide transitions from T à C and from Aà G in Exon 7 of the CYP1A1 gene. Transitions found were non-synonymous single nucleotide polymorphisms resulting in amino acid change from Tyrosine to Histidine and Isoleucine to Valine, respectively. This transition in cattle may affect estrogen and thus, the repeat breeding syndrome.
Key Words: CYP1A1, SNP, Repeat Breeding, ASPCR, Estrogen