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Online Journal of Bioinformatics ©
Volume 1: 26-41, 2001.
An unsupervised neural network approach for discovery
of gene expression patterns in B-cell lymphoma.
Department of Computer Science, Trinity College, Ireland.
Azuaje F, An unsupervised neural network approach for discovery of gene expression patterns in B -cell lymphoma. Online J Bioinformatics 1:26-41, 2001: The automated interpretation of gene expression data may play a crucial role in the classification and treatment of human cancers. In this paper a new computational approach to the discovery and analysis of gene expression patterns is illustrated and applied to the recognition of B-cell malignancies. Using cDNA microarrays data obtained from a previous study, an unsupervised and self-adaptive neural network model known as Growing Cell Structures is able to identify normal and diffuse large B-cell lymphoma (DLBCL) patients. Furthermore, it distinguishes patients with molecularly distinct types of DLBCL without previous knowledge of those subclasses.
Keywords:gene expression analysis, neural networks, data mining, decision support systems, molecular classification of cancer.